Browse all prodrug entries in the database. Comprehensive data on drug design, structure, and chemical properties.
Explore the metabolic pathways, associated enzymes, and source microbes responsible for drug biotransformation.
| Drug Name | CAS Number | DrugBank ID | Strategy |
|---|---|---|---|
| {{ d.name }} | {{ d.cas_number || 'N/A' }} | {{ d.drugbank_id || 'N/A' }} | {{ d.strategy || 'N/A' }} |
| Enzyme Name | UniProt ID | INTEDE ID |
|---|---|---|
| {{ e.name }} | {{ cleanValue(e.uniprot_id) }} | {{ cleanValue(e.intede_id) }} |
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UHGP ID | Species | Length | Identity (%) | E-value | Coverage (%) | Taxonomy |
|---|---|---|---|---|---|---|---|
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{{ m.uhgp_id }} | {{ m.species || 'Unknown' }} | {{ m.length }} |
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{{ m.evalue }} | {{ m.coverage ? (parseFloat(m.coverage)).toFixed(1) + '%' : 'N/A' }} | {{ m.phylum || 'N/A' }} |
| No homologous proteins found matching your criteria. | |||||||
Access our complete datasets for offline analysis. All files are provided in Excel (.xlsx) format with the latest metabolic and taxonomic data.
Contains nearly 200 manually curated prodrug entries, including chemical structures (SMILES), CAS numbers, DrugBank IDs, and clinical design strategies.
Detailed mapping of prodrug-metabolizing enzymes across 10,000+ microbial species, including taxonomy, sequence identity, and E-values.
Integrated bioinformatics tools for high-throughput sequence analysis and microbial database querying.
Batch extract sequences from UHGP-95 database using MGYG IDs. Supports multiple formats and compression.
Perform ultra-fast sequence alignment against the complete UHGP-95 database.
The search is running in the background. You can save the Job ID and retrieve results later.
Data Retention Policy: Calculation results and uploaded sequences are automatically deleted after 7 days.
| Target ID | Identity % | Aln Len | Mismatch | Gap | Q-Start/End | T-Start/End | E-value | Bit Score |
|---|---|---|---|---|---|---|---|---|
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ProMicroDB (Drug-Microbiome Metabolism Database) is a high-quality knowledge engine designed to serve as a comprehensive resource for drug-microbiome metabolism data. Our platform provides a curated repository of relationships between drugs, metabolic enzymes, and associated microbes, enabling researchers to explore the intricate landscape of drug biotransformation by the human microbiome.
On the homepage, you can quickly find entries by typing a Drug Name, DrugBank ID, or CAS Number. The autocomplete system will provide suggestions as you type.
Enter at least 2 characters to trigger the suggestion list. Use arrow keys or your mouse to select the target drug.
Clicking a result will take you directly to the comprehensive metabolism detail page for that drug.
Each drug entry displays structural information and metabolic pathways. The Metabolism Flow diagram visualizes the biotransformation process from the prodrug to its active metabolite.
Enzyme pages provide the protein sequence and detailed mapping of homologous proteins across different microbial species.
Reference IDs for cross-database mapping.
Homology search results against the Unified Human Gastrointestinal Protein (UHGP) catalog.
Our integrated MMseqs2 tool allows you to align your own protein sequences against the full UHGP-95 database (over 20 million proteins) in seconds.
Parameters Guide:
Batch extract and download protein sequences using UHGP/MGYG IDs. You can choose between .faa, .fasta, or .txt formats.
The Statistic Center provides dynamic visualizations of the database content, including the distribution of prodrug design goals, ATC classifications, and taxonomic distribution (from Phylum to Species) of all associated microbes.
If you use ProMicroDB in your research, please cite our work:
For questions, feedback, or data contributions, please contact the development team: